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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45927a15a0d8ca1584e718c28e3dd81d86dc27f2244e991c80a159b516f630c4' 
  AND token = '+ksIY2vzXnSODxXdCDiJEJNnVdJuEm3MY0L9uvciT60=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}