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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3cf8a1299341ec52e73646f35cdd53421da95bc9eb99a67b7fafd516be8a3cdb' 
  AND token = 'ZwuU31XYRK1CaRU2JyjEkTQlo+EHLzyftbaQWjHA8Gc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}